{"_path":"/studies/10","_dir":"studies","_draft":false,"_partial":false,"_locale":"","id":"10","record_id":"10","name_study":"BeLOVE - Berliner Langzeitbeobachtungsstudie für vaskuläre Ereignisse","dzpg_site":"Berlin/Potsdam","description_study":"Cardiovascular disease (CVD) is the leading cause of death worldwide with multiple forms of organ dysfunction, comorbidities, impaired health-related quality of life as well as frailty and dependency in the elderly. The greatest contribution to increased life expectancy between 1980 and 2002 is a reduction in age-specific mortality from cardiovascular diseases. Therefore, it is still necessary to collect and analyze data on development and progression of cardiovascular diseases in order to find new predictors for vascular events. The Berlin Longterm Observation of Vascular Events (BeLOVE) study is designed as a patient-based cohort study to provide a unique scientific structure and high quality data/biomaterial resource for a variety of studies on risk factors, interactions and causal mechanisms of different forms of CVD manifestations in a high-risk population.   The objective of BeLOVE is to identify novel pathophysiological cross-disease mechanisms and treatment targets that determine both short and long-term outcome of high-risk patients with acute vascular disease. In the study patients with an acute index events due to acute cerebrovascular disorder, acute coronary syndrome, or acute heart failure, together with patients without an index event but a comparably increased risk to develop a cardiovascular event (one cohort - four disease entities).","title_pi":"Prof. Dr.","given_name_pi":"Matthias","family_name_pi":"Endres","further_pi":"Prof. Dr. Ulf Landmesser, Prof. Dr. Tobias Pischon, Prof. Dr. Leif-Hendrik Boldt, Prof. Dr. Kai-Uwe Eckardt, Prof. Dr. Holder Gerhardt, Dr. Ulrike Grittner, Prof. Dr. Knut Mai, Prof. Dr. Dominik N. Müller","contact_mail":"joachim.weber@bih-charite.de","paper":"currently in review","website":"https://www.bihealth.org/de/forschung/projekte/belove","trial_number":"DRKS00023323","study_status":"Ongoing (II): Recruitment and data collection ongoing","type_intervention":["Non-interventional"],"type_specification_non_int":["Cohort"],"type_specification_int":[],"setting":"Monocentric","setting_country":"Single","which_country":"Germany","participants":["Patients with specific diseases"],"specific_diseases":["Other"],"mental_disorders":[],"somatic_disorders":["Endocrine, nutritional or metabolic diseases (05)","Diseases of the nervous system (08)","Diseases of the circulatory system (11)"],"recruited":["Hospital","Outpatient"],"n_participants_target":"8000","n_participants_obtained":"~3500","start_recruitment":"2017","min_age":"18","max_age":"-","data_sources":["Biological samples","Cognitive measurements","Imaging data","Medical records","Registries","Interview","Questionnaire","Physiological/biochemical measurements","Omics technology"],"data_sharing":"Yes, there is a plan to make data available","data_sharing_additional":"All of individual participant data collected during the study will be shared according to the consent given by participants. Data will be available beginning in 2022 with no end of data sharing.  Data will be shared with researchers whose proposed use of the data has been approved by the use & access committee of the BeLOVE study which will be established in 2021. Requests and proposals should be directed to: Dr. Joachim Weber (joachim.weber@charite.de) . To gain access the requesters will need to sign an access agreement.  As accompanying documents the study protocol and informed consent forms are available.","planned_follow_ups":"Not planned, but possible","consent_recontact":"Yes","further_components":"Yes","biobank":{"biobank_material":["Blood","PBMC","Urin","Saliva","Other"],"biobank_material_other":"Stool","biobank_blood":["Serum","EDTA","PAXgene/Tempus","Other"],"biobank_blood_other":"Citrate, Heparin","biobank_serum":["clin-chem","Other"],"biobank_serum_other":"various circulating and anti-neuronal Antibodies","biobank_edta":["clin-chem","Proteomics","Other"],"biobank_edta_other":"Metabolomics","biobank_paxgene":["Gene expression","Other"],"biobank_paxgene_other":"GWAS, CHIP, mRNA-Seq","biobank_pbmc":["iPSC","Other"],"biobank_pbmc_other":"single-cell CHIP analysis","biobank_urin":["Other"],"biobank_urin_other":"no data collected yet, only sample storage in biobank","biobank_saliva_other":"no data collected yet, only sample storage in biobank","biobank_saliva":["Other"]},"pi_full":"Prof. Dr. Matthias Endres","_id":"content:studies:10.json","_type":"json","title":"10","_source":"content","_file":"studies/10.json","_stem":"studies/10","_extension":"json"}