{"_path":"/studies/37","_dir":"studies","_draft":false,"_partial":false,"_locale":"","id":"37","record_id":"37","name_study":"Dortmund Vital Study (DVS)","dzpg_site":"Bochum/Marburg","description_study":"The Dortmund Vital Study (DVS) is a longitudinal, population-based cohort study on determinants and consequences of cognitive aging.    The DVS aims to identify influences of biological, lifestyle and environmental factors on physical and mental health across the lifespan and to develop new possibilities for early detection of cognitive decline in aging. The study will shed light on sources of interindividual differences in the alterations of cognitive functioning with increasing age and reveal biological and lifestyle markers contributing to work ability, longevity, and healthy aging. A special focus is on the influences of work and work activity. But also risk factors for cognitive decline, mild cognitive impairment, or even dementia will be evaluated.    The DVS is a multidisciplinary study of the Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo) in Germany, involving the Departments of Ergonomics, Immunology, Psychology and Neurosciences, and Toxicology, as well as numerous national and international collaboration partners.","title_pi":"Prof. Dr.","given_name_pi":"Edmund","family_name_pi":"Wascher","further_pi":"Dr. Patrick D. Gajewski  Dr. Stephan Getzmann","contact_mail":"wascher@ifado.de","contact_phone":"492311084362","paper":"Gajewski PD, Getzmann S, Bröde P, Burke M, Cadenas C, Capellino S, Claus M, Genç E, Golka K, Hengstler JG, Kleinsorge T, Marchan R, Nitsche MA, Reinders J, van Thriel C, Watzl C, Wascher E. (2022). Impact of Biological and Lifestyle Factors on Cognitive Aging and Work Ability in the Dortmund Vital Study: Protocol of an Interdisciplinary, Cross-sectional, and Longitudinal Study  JMIR Res Protoc 2022;11(3):e32352  https://www.researchprotocols.org/2022/3/e32352/authors","website":"https://vital-study.ifado.de/index.php/home","trial_number":"Clinicaltrials.gov: NCT05155397","study_status":"Ongoing (III): Recruitment completed, but data collection ongoing","type_intervention":["Non-interventional"],"type_specification_non_int":["Cohort","Longitudinal","Cross-sectional"],"type_specification_int":[],"setting":"Monocentric","setting_country":"Single","which_country":"Germany","participants":["General population"],"specific_diseases":[],"mental_disorders":[],"somatic_disorders":[],"recruited":["General population"],"n_participants_target":"600","n_participants_obtained":"616","start_recruitment":"2016","min_age":"20","max_age":"70","data_sources":["Biological samples","Cognitive measurements","Imaging data","Questionnaire","Physiological/biochemical measurements","Omics technology"],"data_sharing":"Yes, there is a plan to make data available","data_sharing_additional":"o access research data, scientists of IfADo, as well as external cooperation partners planing to analyze data from the Dortmund Vital Study fill in a proposal form including a short description of the project and the responsible persons. The requested research data will be made available in an anonymized form after consultation with the scientists responsible for the data. Responsible persons include project managers and coordinators of the Dortmund Vital Study in consultation with the IfADo Research Data Management Unit. External scientists who are interested in a cooperation, are ask to contact the coordinators of the Dortmund Vital Study via email: dvs@ifado.de.    After primary analyses and publication of the main results, the research data and the scripts used for data analyses shall be made available in repositories for secondary analyses. The transfer agreement will be prepared by the coordinators of the Dortmund Vital Study in consultation with the IfADo Research Data Management Unit. Data access will be restricted and will require a structured project proposal. Interoperability will be guaranteed by metadata included in the SQL database and common data formats (eg, BIDS) to enhance exchange, management, and documentation. Data identifiers (digital object identifiers) will be assigned at least until the end of the projects.","planned_follow_ups":"Yes","consent_recontact":"Yes","further_components":"Yes","comments":"SInce 2021 the first follow-up testing is conducted.","biobank":{"biobank_material":["PBMC","Other"],"biobank_material_other":"Serum","biobank_blood":[],"biobank_serum":[],"biobank_edta":[],"biobank_paxgene":[],"biobank_pbmc":["Other"],"biobank_pbmc_other":"Immune cell status by flow cytometry","biobank_urin":[],"biobank_saliva":[]},"pi_full":"Prof. Dr. Edmund Wascher","_id":"content:studies:37.json","_type":"json","title":"37","_source":"content","_file":"studies/37.json","_stem":"studies/37","_extension":"json"}