Ongoing (II): Recruitment and data collection ongoing
In line with the Research Domain Criteria initiative, the Clinical Deep Phenotyping (CDP) study is using a multimodal approach to reveal the neurobiological underpinnings of clinically relevant schizophrenia subgroups (characterized with MINI interview according to DSM-V) by performing a broad transdiagnostic clinical characterization with standardized clinical scores and neurocognitive assessments (BACS), multimodal neuroimaging (sMRI, rsfMRI, ASL, MRS, DTI), electrophysiological assessments (rsEEG, P300, TMS-based neurophysiology), retinal investigations (OCT, ERG), and omics-based analyses of blood (i.e. neuroplasticity, neurodegenerative and neuroinflammatory biomarkers) and cerebrospinal fluid. Moreover, to bridge the translational gap in biological psychiatry the study includes the assessment of polygenic risk scores and in vitro investigations on human-induced pluripotent stem cells, which are available from a subset of participants.
https://pubmed.ncbi.nlm.nih.gov/37215661/
DRKS00024177