LöwenKIDS

ID

34

DZPG Site

Jena/Magdeburg/Halle
General Information
Status

Ongoing (III): Recruitment completed, but data collection ongoing

Description

The overall goal of our birth cohort is to record a complete history of respiratory and gastrointestinal infections in infancy in order to investigate the effect of pattern, timing and sequence of infections and other risk factors influencing the immune response on the development of asthma and atopic diseases from a life-course perspective. Therefore, we enrolled 782 newborns in 5 Germn study centres. During the first 6 years, all parents are asked to fill in a symptom diary every day, take nasal or stool samples whenever their child shows predefined respiratory or gastrointestinal symptoms, and collect asymptomatic nasal and stool samples in asymptomatic children once a year.

Paper

Cohort profile: The LoewenKIDS Study - life-course perspective on infections, the microbiome and the development of the immune system in early childhood https://academic.oup.com/ije/article/48/4/1042/5366219

Trial Number

NCT02654210

Contact
PI

Prof. Dr. Rafael Mikolajczyk

Survey Results
Is it an interventional or non-interventional study?
  • Non-interventional
Specification of study type
  • Birth cohort
Is it a mono- or multicentric study?

Multicentric

Number of sites

5

Is it a single or multi country study?

Single

Which country?

Germany

Who are participants?
  • General population
Recruitment setting
  • General population
Target sample size

500-1000

Obtained sample size

792

Start of recruitment

2014

Minimum age of participants

0

Maximum age of participants

3 months

Data sources for the study
  • Biological samples
  • Medical records
  • Questionnaire
Is it planned to share the data?

Yes, there is a plan to make data available

Are further follow-ups planned?

Yes

Is there consent to re-contact participants?

Yes

Is the implementation of further study components possible?

Yes

Biobank Module
Which material did you collect?
  • Blood
  • PBMC
  • Saliva
  • Other
Which other material did you collect?

Nasal and stool samples (symptomatic and asymptomatic)

What type of blood collection tubes did you use?
  • Serum
  • EDTA
Which type of data did you collect from Serum?
  • Other
Which other data did you collect from Serum?

Antibody titre

Which type of data did you collect from PBMC?
  • Other
Which other data did you collect from PBMC?

Next-generation sequencing of T and B cell immune repertoires

Which type of data did you collect from saliva?
  • Genetic
  • Epigenetic
View raw data