Dortmund Vital Study (DVS)

ID

37

DZPG Site

Bochum/Marburg
General Information
Status

Ongoing (III): Recruitment completed, but data collection ongoing

Description

The Dortmund Vital Study (DVS) is a longitudinal, population-based cohort study on determinants and consequences of cognitive aging. The DVS aims to identify influences of biological, lifestyle and environmental factors on physical and mental health across the lifespan and to develop new possibilities for early detection of cognitive decline in aging. The study will shed light on sources of interindividual differences in the alterations of cognitive functioning with increasing age and reveal biological and lifestyle markers contributing to work ability, longevity, and healthy aging. A special focus is on the influences of work and work activity. But also risk factors for cognitive decline, mild cognitive impairment, or even dementia will be evaluated. The DVS is a multidisciplinary study of the Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo) in Germany, involving the Departments of Ergonomics, Immunology, Psychology and Neurosciences, and Toxicology, as well as numerous national and international collaboration partners.

Paper

Gajewski PD, Getzmann S, Bröde P, Burke M, Cadenas C, Capellino S, Claus M, Genç E, Golka K, Hengstler JG, Kleinsorge T, Marchan R, Nitsche MA, Reinders J, van Thriel C, Watzl C, Wascher E. (2022). Impact of Biological and Lifestyle Factors on Cognitive Aging and Work Ability in the Dortmund Vital Study: Protocol of an Interdisciplinary, Cross-sectional, and Longitudinal Study JMIR Res Protoc 2022;11(3):e32352 https://www.researchprotocols.org/2022/3/e32352/authors

Trial Number

Clinicaltrials.gov: NCT05155397

Contact
PI

Prof. Dr. Edmund Wascher

Further PIs

Dr. Patrick D. Gajewski Dr. Stephan Getzmann

Survey Results
Is it an interventional or non-interventional study?
  • Non-interventional
Specification of study type
  • Cohort
  • Longitudinal
  • Cross-sectional
Is it a mono- or multicentric study?

Monocentric

Is it a single or multi country study?

Single

Which country?

Germany

Who are participants?
  • General population
Recruitment setting
  • General population
Target sample size

600

Obtained sample size

616

Start of recruitment

2016

Minimum age of participants

20

Maximum age of participants

70

Data sources for the study
  • Biological samples
  • Cognitive measurements
  • Imaging data
  • Questionnaire
  • Physiological/biochemical measurements
  • Omics technology
Is it planned to share the data?

Yes, there is a plan to make data available

Additional information about data sharing

o access research data, scientists of IfADo, as well as external cooperation partners planing to analyze data from the Dortmund Vital Study fill in a proposal form including a short description of the project and the responsible persons. The requested research data will be made available in an anonymized form after consultation with the scientists responsible for the data. Responsible persons include project managers and coordinators of the Dortmund Vital Study in consultation with the IfADo Research Data Management Unit. External scientists who are interested in a cooperation, are ask to contact the coordinators of the Dortmund Vital Study via email: dvs@ifado.de. After primary analyses and publication of the main results, the research data and the scripts used for data analyses shall be made available in repositories for secondary analyses. The transfer agreement will be prepared by the coordinators of the Dortmund Vital Study in consultation with the IfADo Research Data Management Unit. Data access will be restricted and will require a structured project proposal. Interoperability will be guaranteed by metadata included in the SQL database and common data formats (eg, BIDS) to enhance exchange, management, and documentation. Data identifiers (digital object identifiers) will be assigned at least until the end of the projects.

Are further follow-ups planned?

Yes

Is there consent to re-contact participants?

Yes

Is the implementation of further study components possible?

Yes

Biobank Module
Which material did you collect?
  • PBMC
  • Other
Which other material did you collect?

Serum

Which type of data did you collect from PBMC?
  • Other
Which other data did you collect from PBMC?

Immune cell status by flow cytometry

View raw data